A 44-year-old woman comes to the physician for a 12-hour history of a swollen and painful left thigh. Vitals are normal. Physical examination shows infraorbital puffiness, mild pre-sacral edema, and moderate bilateral pedal edema. Duplex ultrasound of the left thigh confirms the diagnosis. Which of the following is most likely to be seen in this patient?
Decreased activity of factor VIII
Disseminated intravascular coagulation
Failure to cleave von Willebrand factor multimers
Membranous glomerulonephropathy
Reduced ankle/brachial indices
