A 28-year-old woman comes to the physician because of a 4-month history of fatigue. Laboratory studies show:
Hemoglobin 11.0 g/dL
⇒ Hemoglobin A2 5% (NR 2-4)
⇒ Hemoglobin F 2% (NR 0-2)
MCV 70 fL
Prothrombin time 13 seconds
Partial thromboplastin time 37 seconds
Which of the following is most likely to be seen in this patient?
Abnormal clotting factor synthesis
Deficiency of iron
Dysfunctional alpha globin chain
Production of hydrophobic hemoglobin variant
Splice site mutation
