A 6-year-old boy is brought to the physician for a 1-month history of worsening peripheral neuropathy. Hemoglobin is 11 g/dL. Serum LDH is elevated. A sweat chloride test is measured at 20 mmol/L. A small bowel biopsy and blood smear are shown.
Which of the following is the most likely explanation for this patient’s presentation?
Deficiency of apolipoprotein-CII
Impaired chylomicron absorption
Increased hepatic production of VLDL
Liver failure
Misfolded channel
