A 24-year-old man is evaluated as part of a research study in which his family demonstrates a single nucleotide polymorphism that results in lesser expression of phenylethanolamine-N-methyltransferase (PNMT). Which of the following is most likely to be seen in this patient in comparison to individuals without this polymorphism?
Decreased synthesis of epinephrine in the adrenal medulla
Decreased synthesis of pregnenolone in the adrenal cortex
Increased risk of adrenal cortical tumor secreting aldosterone
Increased risk of adrenal medullary tumor secreting catecholamines
Upregulation of production of dehydroepiandrosterone sulfate
