A 40-year-old man comes to the physician because of a 4-month history of gradually increasing fatigue, sore hands, and right upper quadrant discomfort. He drinks alcohol socially and does not smoke. On physical examination, the liver edge is palpable beneath the costal margin and hyperpigmentation of the forearms. Fasting glucose is 138 mg/dL. Which of the following is most likely to be seen in this patient’s condition?
Brown pigment deposition in hepatocytes, confirmed by Prussian blue staining
Hepatocyte necrosis with copper accumulation in periportal hepatocytes
Intracytoplasmic PAS-positive, diastase-resistant globules in periportal hepatocytes
Perivenular hepatocyte ballooning with Mallory hyaline
Steatosis with focal inflammation and hepatocyte necrosis
