A 3-year-old boy is brought to the physician by his mother for recurrent skin and respiratory infections. His mother report that he has had multiple episodes of pneumonia and cellulitis for the past couple years. On exam, he has silvery hair, nystagmus, and mild hepatosplenomegaly. He has fairer skin compared to his 6-year-old sister. A peripheral blood smear shows neutrophils containing giant granules. Which of the following is most likely characteristic of this patient’s condition?
Autosomal dominant; Defective fusion of phagosomes with lysosomes in neutrophils
Autosomal dominant; Deficient expression of integrins required for neutrophil adhesion to endothelium
Autosomal dominant; Impaired impaired interleukin receptor function
Autosomal dominant; Impaired NADPH oxidase activity leading to defective respiratory burst
Autosomal dominant; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
Autosomal recessive; Defective fusion of phagosomes with lysosomes in neutrophils
Autosomal recessive; Deficient expression of integrins required for neutrophil adhesion to endothelium
Autosomal dominant; Deficient expression of integrins required for neutrophil adhesion to endothelium
Autosomal dominant; Impaired impaired interleukin receptor function
Autosomal dominant; Impaired NADPH oxidase activity leading to defective respiratory burst
Autosomal dominant; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
Autosomal recessive; Defective fusion of phagosomes with lysosomes in neutrophils
Autosomal recessive; Deficient expression of integrins required for neutrophil adhesion to endothelium
Autosomal recessive; Impaired impaired interleukin receptor function
Autosomal recessive; Impaired NADPH oxidase activity leading to defective respiratory burst
Autosomal recessive; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
Autosomal recessive; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
X-linked recessive; Defective fusion of phagosomes with lysosomes in neutrophils
X-linked recessive; Deficient expression of integrins required for neutrophil adhesion to endothelium
X-linked recessive; Deficient expression of integrins required for neutrophil adhesion to endothelium
X-linked recessive; Impaired impaired interleukin receptor function
X-linked recessive; Impaired NADPH oxidase activity leading to defective respiratory burst
X-linked recessive; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
X-linked recessive; Impaired T cell cytoskeletal rearrangement leading to defective immune synapse formation
