A 7-year-old boy undergoes a bone marrow transplant following chemoradiotherapy for acute lymphoblastic leukemia. Two weeks following the operation he develops a diffuse rash, worsening fatigue, and profuse watery diarrhea. Laboratory analysis shows elevation of hepatic transaminases. Which of the following is most likely responsible for this patient’s presentation?
Antibody response against graft antigens
Cytokine response mediated by macrophages and Toll-like receptors
B cell-mediated immune response targeting recipient antigens
Host T cell response against donor antigens
T cell response of donor against recipient
Cytokine response mediated by macrophages and Toll-like receptors
B cell-mediated immune response targeting recipient antigens
Host T cell response against donor antigens
T cell response of donor against recipient
