HY USMLE Q #1370 – Biochem + Pharm

A 49-year-old woman comes to the physician for a 2-day history of coryza, headache, and fatigue. Temperature is 100.3 F. She has a mild dry cough, no tonsillar exudates, and no lymphadenopathy. Warm saline gargle is given for symptomatic management. Oxymetazoline nasal spray is also given. Which of the following is the most likely molecular impact of use of this intra-nasal pharmacologic agent?