A 55-year-old man comes to the physician for a 4-month history of progressively worsening fatigue, early satiety, and unintentional weight loss. Physical examination shows splenomegaly extending below the left costal margin. Leukocytes are 90,000/μL, including myelocytes, metamyelocytes, and promyelocytes The leukocyte alkaline phosphatase (LAP) score is low. Which of the following is most likely to be seen in this patient?
A) Cytoplasmic extensions
B) Facial plethora with a thymic lesion
C) Myeloperoxidase- and azurophilic granule-containing rods
D) Oncogenic tyrosine kinase
E) Warm autoimmune hemolytic anemia
