HY USMLE Q #1396 – Rheumatology

A 56-year-old woman comes to the physician for a 1-week history of progressive pain in her left knee. She says her knee occasionally “acts up” and something similar has happened about 3 times before over the past 5 years. Vitals are normal. Current medications are hydrochlorothiazide for hypertension and esomeprazole for a peptic ulcer. Physical examination shows a tender and erythematous left knee. Laboratory studies are unremarkable. Arthrocentesis is performed and shown below.

The mechanism of the most appropriate pharmacologic therapy for this
patient’s acute presentation is most similar to which of the following agents?

A) Cimetidine
B) Dicloxacillin
C) Fludrocortisone
D) Mebendazole
E) Naproxen