A 32-year-old woman comes to the physician for a 3-month history of restlessness and feeling periodic “hot flashes,” as though she’s going through menopause. Vitals show a slightly elevated heart rate. Past medical history is unremarkable. She takes no medications. Her brother has SLE.
Which of the following is the most likely explanation for this patient’s findings?
A) Autoantibodies against nuclear Smith antigen
B) Autoantibodies against mitochondrial proteins
C) Autoantibodies against enzyme targeting tyrosine residues
D) Autoantibodies against thyroglobulin
E) Autoantibodies against thyrotropin binding site
