A 42-year-old man is evaluated in hospital following a total thyroidectomy for medullary thyroid carcinoma. He is RET positive and also undergoes serial blood pressure checks. A urinary metanephrine check was performed preoperatively and was negative. Serum calcium is 8.2 mg/dL and phosphate 4.7 mg/dL. The deficient hormone responsible for this patient’s acute electrolyte disturbance normally carries out which of the following mechanisms?
A) Decreases late-distal convoluted tubule calcium channel insertion
B) Decreases phosphate reabsorption in the distal convoluted tubule
C) Directly stimulates osteoclasts to induce bone resorption
D) Increases 25-hydroxylase activity in the proximal convoluted tubule
E) Increases intraosseous paracrine signaling
