A 52-year-old man comes to the physician for a health maintenance examination. He has no past medical history. One month ago, his blood pressure was recorded at 150/92. Two weeks ago, two blood pressure measurements, 15 minutes apart, were 150/90 and 148/91. Today, his blood pressure is 150/90. His BMI is 23. He does not drink or smoke. HbA1c is 5%. Urinalysis and blood work are both normal. Hydrochlorothiazide is commenced. Which of the following is most likely to be seen in this patient as a result of this pharmacotherapy?
A) Decreased TRPV5 channel activity
B) Decreased apical sodium/calcium symport activity
C) Increased apical calcium antiport activity
D) Increased basolateral calcium reabsorption
E) Increased basolateral sodium reabsorption
