A 6-year-old boy is brought to physician by his parents for recurrent infections since early infancy. He has had multiple episodes of otitis media and pneumonia requiring antibiotics, and his parents report frequent episodes of diarrhea. Physical examination shows diffuse eczematous rash involving the flexural surfaces and trunk with areas of excoriation. The infant bruises easily, and his parents note frequent nosebleeds and prolonged bleeding after heel sticks. Which of the following is the most likely explanation for this patient’s presentation?
A) Chediak-Higashi syndrome
B) Hyper IgM syndrome
C) IgA deficiency
D) Job syndrome
E) Wiskott-Aldrich syndrome
