A 61-year-old woman comes to the physician for a follow-up appointment. She has no past medical history but inquires about how she can improve her overall health. She says she has heard saturated fats are bad for her blood vessels and heart. Which of the following is the most predominant mechanism behind the effect of saturated fat on cardiovascular health?
A) Decreased LDL receptor expression on adipocytes
B) Decreased LDL receptor expression on hepatocytes
C) Direct inhibition of sterol-regulatory element binding protein-2 (SREBP-2) transcription
D) Increased hepatic production of LDL
E) Increased plasma clearance of HDL
