A 9-year-old girl is brought to the physician because of progressive fatigue and increased urination for the past week. Pulse is 110/min. Physical examination shows dry mucous membranes and poor skin turgor. Fasting serum glucose is 400 mg/dL. Which of the following best explains the increased urinary output in this patient?
Baroreceptor-mediated ADH release
Disruption of loop of Henle ion gradient
Increased glomerular filtration
Ketonuria
Metabolic acidosis
