A 12-year-old boy is brought to the emergency department for a 1-hour history of difficulty breathing. His symptoms do not improve significantly with albuterol. After intravenous methylprednisolone is administered, marked clinical improvement is seen. Which of the following best explains the mechanism for this patient’s improvement?
Binding to cell-surface receptor with induction of JAK/STAT tyrosine kinase
Binding to cytosolic receptor, translocation to the nucleus, and activation of target genes
Binding to G-protein-coupled receptor and inhibition of adenylyl cyclase
Binding to G-protein-coupled receptor and stimulation of adenylyl cyclase
Binding to G-protein-coupled receptor and stimulation of phosphoinositide turnover
