HY USMLE Q #641 – Extracellular matrix proteins

A 14-year-old girl is brought to the emergency department because of painful blisters on her trunk for the past 24 hours. She has no significant past medical history. She has not taken any medications. Examination shows tense bullae on the torso. Biopsy shows subepidermal blister formations. A direct immunofluorescence is shown.

 

 

 

 

 

Which of the following structures is most likely to be targeted in this patient?

Adherens junction
Desmosome
Gap junction
Hemidesmosome
Tight junction