HY USMLE Q #643 – Biochem / Pharm

A 25-year-old man comes to the physician for a health maintenance examination. He has a 1-year history of worsening auditory hallucinations and has recently been started on aripiprazole. Which of the following sets of molecular findings is most likely to be seen in this patient?

D1 agonism; ↑ IP3
D1 agonism; ↓ IP3
D1 agonism; ↑ cAMP
D1 agonism; ↓ cAMP
D1 antagonism; ↑ IP3
D1 antagonism; ↓ IP3
D1 antagonism; ↑ cAMP
D1 antagonism; ↓ cAMP
D2 agonism; ↑ IP3
D2 agonism; ↓ IP3
D2 agonism; ↑ cAMP
D2 agonism; ↓ cAMP
D2 antagonism; ↑ IP3
D2 antagonism; ↓ IP3
D2 antagonism; ↑ cAMP
D2 antagonism; ↓ cAMP