HY USMLE Q #663 – Hematology (difficult)

A 39-year-old woman is brought to emergency because of a 1-day history of fever, confusion, and lethargy. Temperature is 38 C (100.4 F). Physical examination shows scattered ecchymoses and petechiae. Neurologic examination shows mild-moderate generalized weakness. She is oriented to person but not place or time. Laboratory studies show:

Hemoglobin                                                                                 9.5 g/dL
Leukocytes                                                                                   7500/μL
Platelets                                                                                        20,000/μL
Prothrombin time                                                                    12 seconds
Partial thromboplastin time                                              34 seconds
Blood urea nitrogen                                                               26 mg/dL

A Coombs test is negative. An intravenous exchange transfusion is started. Within a week, her condition rebounds. Which of the following is most likely to be seen in this patient?

Decreased activity of anti-proteinase 3
Decreased activity of HLA B27 reductase
Decreased activity of metalloprotease
Decreased activity of myeloperoxidase
Increased activity of plasmin