A 5-year-old girl is brought to the physician by her mother for impulse eating since the age of 3 years. She is at the 50th percentile for height and 99th percentile for weight. Physical examination shows almond-shaped eyes and a prominent nasal bridge. There is hypotonia of the extremities. Mental status examination shows delayed motor and speech development. Fluorescent in situ hybridization detects no deletions on chromosome 15. Which of the following is the most likely explanation for this patient’s presentation?
Maternal imprinting
Maternal uniparental disomy
Paternal imprinting
Paternal uniparental disomy
