A 31-year-old woman comes to the physician for a 3-month history of bilateral hand, wrist, and knee pain. Antibody titers are positive. In addition to medical management of this patient’s symptoms, the most appropriate initial recommendation for slowing progression of this patient’s disease bears which of the following mechanisms of action?
Guanine N7 alkylation
Inhibition of dihydrofolate reductase
Inhibition of dihydroorotate dehydrogenase
Inhibition of soluble TNF-α
Inhibition of TNF-α receptor
