A 56-year-old woman presents to the physician for a follow-up appointment. She has hypercalcemia, nephrotic syndrome, and markedly elevated serum IgG kappa. Bone marrow biopsy confirms the diagnosis and is shown. Bortezomib is initiated. Which of the following is most likely to occur as a result of this therapy.
Decreased B cell activation
Decreased CD4+ T cell activation
Decreased CD8+ T cell activation
Decreased isotype class-switching
Decreased NK cell activity
