HY USMLE Q #823 – Biochemistry

A 59-year-old woman comes to the physician for a follow-up examination. Biopsy specimen is shown. Which of the following combinations of findings is most likely in this patient?

  ↑ Glucokinase; ↑ Pyruvate carboxylase; ↑ GLUT4 expression
 ↑ Glucokinase; ↓ Pyruvate carboxylase; ↑ GLUT4 expression
 ↑ Glucokinase; ↑ Pyruvate carboxylase; ↓ GLUT4 expression
  ↑ Glucokinase; ↓ Pyruvate carboxylase; ↓ GLUT4 expression
  Glucokinase; ↑ Pyruvate carboxylase; ↑ GLUT4 expression
  Glucokinase; ↓ Pyruvate carboxylase; ↑ GLUT4 expression
  Glucokinase; ↑ Pyruvate carboxylase; ↓ GLUT4 expression
  Glucokinase; ↓ Pyruvate carboxylase; ↓ GLUT4 expression