A 24-year-old man partakes in a research study in which Drug X is administered, followed by sodium bicarbonate to facilitate elimination. Which of the following combinations of properties of Drug X is most likely to reflect maximal elimination?
↑ Plasma protein binding; ↑ Volume of distribution; pKa 9.0
↑ Plasma protein binding; ↑ Volume of distribution; pKa 5.0
↑ Plasma protein binding; ↓ Volume of distribution; pKa 9.0
↑ Plasma protein binding; ↓ Volume of distribution; pKa 5.0
↓ Plasma protein binding; ↑ Volume of distribution; pKa 9.0
↓ Plasma protein binding; ↑ Volume of distribution; pKa 5.0
↓ Plasma protein binding; ↓ Volume of distribution; pKa 9.0
↓ Plasma protein binding; ↓ Volume of distribution; pKa 5.0
