A 61-year-old man with chronic venous insufficiency is brought to hospital by his wife for a 12-hour history of confusion. He has a 4-day history of worsening redness of his right leg which he has not sough treatment for. Vitals are: temperature 102 F, HR 100, RR 16, BP 90/50. Which of the following cytokines is most saliently responsible for this patient’s hypotension?
IL-1
IL-2
IL-6
IL-12
IFN-β
TNF-α
