A 16-year-old girl is brought to the physician by her mother because she has not had a menstrual period for 8 months. Menarche occurred at the age of 11 years. Menses had occurred at regular 28-day intervals until she began a weight-loss regimen on year ago. BMI is 17. She says that she eats only 700 calories daily and runs 10 miles per day. Which of the following is most likely to be seen in this patient?
↑ Leptin; ↑ GnRH pulsation; ↑ Luteal progesterone
↑ Leptin; ↓ GnRH pulsation; ↑ Luteal progesterone
↑ Leptin; ↑ GnRH pulsation; ↓ Luteal progesterone
↑ Leptin; ↓ GnRH pulsation; ↓ Luteal progesterone
↓ Leptin; ↑ GnRH pulsation; ↑ Luteal progesterone
↓ Leptin; ↓ GnRH pulsation; ↑ Luteal progesterone
↓ Leptin; ↑ GnRH pulsation; ↓ Luteal progesterone
↓ Leptin; ↓ GnRH pulsation; ↓ Luteal progesterone
