A 62-year-old woman comes to the physician for a follow-up appointment following a biopsy confirming renal cell carcinoma. Which of the following is most likely to indicate the need for nephrectomy in this patient?
High Ki-67 index and 1:1 nuclear:cytoplasm ratio
Low Ki-67 index and 1:1 nuclear:cytoplasm ratio
Highly anaplastic cells with high mitoses confined to basement membrane
Immature morphology, high Ki-67 index
Well-differentiated, slowly dividing cells deep to basement membrane
