HY USMLE Q #880 – Hematology / Biochemistry

A 32-year-old woman comes to the physician for a 3-day history of blistering lesions on her face, arms, and hands. She has had recurrent episodes of such lesions for many years. She has taken no recent medications. Serum total porphyrin is increased. Urine uroporphyrin III is increased. Which of the following is most likely to be seen in this patient?

  Decreased ferrochelatase activity
  Decreased δ-ALA dehydratase activity
  Decreased porphobilinogen deaminase activity
  Howell-Jolly bodies
  Increased serum succinyl-CoA