A 32-year-old man is brought to hospital for fever and confusion. Vitals are: temperature 103 F, HR 100, RR 16, BP 90/50. Leukocyte count is 24,000/μL. Physical examination shows a right lower lobe consolidation with dullness to percussion. Which of the following is most saliently responsible for this patient’s hypotension?
IL-1
IL-2
IL-6
TGF-β
TNF-α