A 3-month-old boy is brought to the physician by her mother because of recurrent sinopulmonary infections since birth. Physical examination shows diffuse hypopigmentation. A peripheral blood smear shows giant granules within neutrophils. Which of the following is the most likely explanation for these findings?
Deficiency of CD18/LFA-1 integrin
Failure of double-stranded DNA break repair
Impaired phagolysosomal fusion
Interleukin-2 receptor deficiency
Tyrosine kinase abnormality
