HY USMLE Q #944 – Hematology

A 61-year-old man comes to the physician because of 1-month history of progressive fatigue and pain in his left arm and back. His only medication is hydrochlorothiazide for hypertension. Physical examination shows pale mucous membranes and tenderness to palpation over the left humerus and diffusely over the back. Laboratory studies show: Hb 9 g/dL; Ferritin 150 ng/dL (NR 25-300); WBCs 8,000/μL; platelets 200,000/μL. Serum calcium is 10.5 g/dL. A photomicrograph of a peripheral blood smear is shown. Which of the following is most likely to develop in this patient?

  Holosystolic murmur that increases with inspiration
  Hypothyroidism
  Loud P2
  Nephrotic syndrome
  Reduced ejection fraction