A 33-year-old man is brought to the physician for a 2-day history of fever and photophobia. He has history of IV drug use. Temperature is 103 F. Physical examination shows a stiff neck. Cerebrospinal fluid analysis shows:
RBCs 1-3/μL (NR <1)
WBCs Polymorphonuclear cells 200/μL (NR <5)
Glucose 40 mg/dL (NR 50-80)
Protein 120 mg/dL (NR 15-60)
Which of the following is the most appropriate pharmacologic therapy?
Acyclovir
Amphotericin B
Flucytosine
Methylprednisolone
Vancomycin + ceftriaxone
