A 20-year-old woman comes to the physician for a follow-up appointment. She has a long-standing history of menorrhagia and epistaxis. Laboratory studies show:
Hemoglobin 10 g/dL
Platelets 170,000/μL
Prothrombin time 12 seconds
Partial thromboplastin time 30 seconds
Bleeding time 9 minutes
Which of the following is the most likely explanation for these findings?
Antibodies against glycoproteins IIb/IIIa
Failure of cleavage of von Willebrand factor multimers
Impaired gamma-carboxylation of clotting factors
Impaired platelet adhesion
Insufficiency of factor VIII
