Microbiology pharm – Hepatitis C drugs

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HY points about each drug followed by a quiz at the end

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Hepatitis C

Ledipasvir, Ombitasvir, Velpatasvir

OVAL → Ombitasvir, Velpitasvir, -Asvir, Ledipasvir

MOA of Ledipasvir, Ombitasvir, Velpatasvir?

Sofosbuvir, Dasabuvir

MOA of Sofosbuvir, Dasabuvir?

Grazoprevir, Simeprevir

MOA of grazoprevir, simeprevir?

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1. MOA of Ledipasvir?

2. MOA of sofosbuvir?

3. MOA of grazoprevir?

4. MOA of dasabuvir?

5. MOA of ombitasvir?

6. MOA of simeprevir?

7. MOA of velpatasvir?

8. What is NS5A?

Phosphoprotein used in RNA replication

Protease

RNA-dependent RNA polymerase

9. What is NS5B?

Phosphoprotein used in RNA replication

Protease

RNA-dependent RNA polymerase

10. What is NS3/4A?

Phosphoprotein used in RNA replication

Protease

RNA-dependent RNA polymerase

11. Name three drugs that inhibit NS5A.

12. Name two drugs that inhibit NS5B.

13. Name two drugs that inhibit NS3/4A.