A 27-year-old man comes to the physician because of 12-hour history of abdominal pain and vomiting. Since infancy, he has had yellow greasy plaques on the skin and recurrent abdominal pain following consumption of fatty meals. Physical examination shows lipema retinalis and periorbital xanthomata. His plasma appears milky. Which of the following is the most likely explanation for these findings?
Deficiency of apolipoprotein B48
Deficiency of apolipoprotein C-II
Deficiency of hormone-sensitive lipase
Deficiency of LDL receptor
Increased hepatic production of VLDL
