HY USMLE Q #1534 – Biochemistry

A 7-year-old girl is brought to the physician for a 3-day history of increasing thirst and urination. She has also had intermittent vomiting during this time. She recently recovered from an upper respiratory tract viral infection about two weeks ago. Which of the following combinations of biochemical changes is most likely to be seen in this patient?

A) ↑ Polyubiquitination; ↑ Glucokinase; ↑ Glycogen phosphorylase
B) ↑ Polyubiquitination; ↑ Glucokinase; ↓ Glycogen phosphorylase
C) ↑ Polyubiquitination; ↓ Glucokinase; ↑ Glycogen phosphorylase
D) ↑ Polyubiquitination; ↓ Glucokinase; ↓ Glycogen phosphorylase
E) ↓ Polyubiquitination; ↑ Glucokinase; ↑ Glycogen phosphorylase
F) ↓ Polyubiquitination; ↑ Glucokinase; ↓ Glycogen phosphorylase
G) ↓ Polyubiquitination; ↓ Glucokinase; ↑ Glycogen phosphorylase
H) ↓ Polyubiquitination; ↓ Glucokinase; ↓ Glycogen phosphorylase