A 49-year-old man comes to the physician for a follow-up appointment. His blood pressure 2 months ago was 150/90. He attempted lifestyle modification with limited success. His blood pressure today is 145/92. He is commenced on hydrochlorothiazide. Which of the following is most likely to be seen in this patient as a result of this pharmacotherapy?
A) Calciuresis
B) Inhibition of early-DCT antiporter
C) Inhibition of late-DCT symporter
D) Reduction in cortical collecting duct ENaC activity
E) Secretion of potassium via ROMK
