A 49-year-old woman comes to the physician for a 2-week history of progressive muscle soreness. She has a history of hypertension and dyslipidemia managed with hydrochlorothiazide, atorvastatin, and gemfibrozil. Which of the following is the most likely explanation for this patient’s presentation?
A) Decreased activation of PPAR-α
B) Decreased activation of PPAR-γ
C) Increased mevalonate
D) Increased activation of PPAR-γ
E) P-450 interaction
