HY USMLE Q #940 – Biochemistry

An 8-year-old girl is brought to the physician because of a 2-week history of frequent thirst and urination. She has lost 5 pounds during this time. Serum glucose is 300 mg/dL. Urinalysis shows 2+ ketones. Blood pH is 7.2. Appropriate treatment is initiated. Which of the following combinations of enzyme activities is most likely to occur as a result of this treatment?

  ↑ Glucokinase; ↑ Glucose-6-phosphatase; ↑ Glycogen phosphorylase
 ↑ Glucokinase; ↑ Glucose-6-phosphatase; ↓ Glycogen phosphorylase
  ↑ Glucokinase; ↓ Glucose-6-phosphatase; ↑ Glycogen phosphorylase
  ↑ Glucokinase; ↓ Glucose-6-phosphatase; ↓ Glycogen phosphorylase
  ↓ Glucokinase; ↑ Glucose-6-phosphatase; ↑ Glycogen phosphorylase
  ↓ Glucokinase; ↑ Glucose-6-phosphatase; ↓ Glycogen phosphorylase
  ↓ Glucokinase; ↓ Glucose-6-phosphatase; ↑ Glycogen phosphorylase
  ↓ Glucokinase; ↓ Glucose-6-phosphatase; ↓ Glycogen phosphorylase